ANTICANCER STUDIES OF NOVEL 2, 4-DISUBSTITUTED -1, 5 -DIPHENYL -1H-IMIDAZOLE DERIVATIVES
نویسندگان
چکیده
منابع مشابه
Anticancer Studies of Novel 2 , 4 - Disubstituted - 1 , 5 - Diphenyl - 1 H - Imidazole Derivatives
In the present work a series of novel 2,4-disubstituted -1, 5 -diphenyl substituted -1H-imidazole derivatives were screened for anticancer activity using human liver cancer cell line. Derivatives were evaluated for anticancer activities against Hep G2 (Human liver cancer) cell lines. Newly synthesized compounds A-IVn, A-IVo,B-IVb, B-IVc, B-IVd, and B-IVe showed highly significant cytotoxic acti...
متن کامل2-(4-Bromophenyl)-1-pentyl-4,5-diphenyl-1H-imidazole
The title compound, C26H25BrN2, is isomorphous with the chloro derivative [2-(4-chloro-phen-yl)-1-pentyl-4,5-diphenyl-1H-imidazole; Mohamed et al. (2013 ▶). Acta Cryst. E69, o846-o847]. The two phenyl rings and the 4-bromo-phenyl ring are oriented at dihedral angles of 30.1 (2), 64.3 (3) and 42.0 (2)°, respectively, with respect to the imidazole ring. In the crystal, mol-ecules stack in columns...
متن کامل2-(4-Chlorophenyl)-4,5-diphenyl-1-(prop-2-en-1-yl)-1H-imidazole
The title compound, C24H19ClN2, crystallizes with two independent mol-ecules in the asymmetric unit. The prop-2-enyl substituents on the imidazole rings adopt similar conformations in the two mol-ecules. The 4-and 5-substituted phenyl rings and the benzene ring make dihedral angles of 67.06 (8), 5.61 (8) and 41.09 (8)°, respectively, with the imadazole ring in one mol-ecule and 71.53 (8), 28.85...
متن کاملSynthesis, Characterization and Anticonvulsant Activity of Some Novel 4, 5-Disubstituted-1, 2, 4-Triazole Derivatives
Article history: Received on: 07/02/2017 Accepted on: 21/03/2017 Available online: 30/07/2017 The current therapy of epilepsy is associated with a number of side effects including sedation and hypnosis. Newer improved molecules are needed with lesser side effects and with improved physical properties. In view of these facts, a series of novel 4, 5-disubstituted-1,2,4-triazoles (6a-o) were synth...
متن کامل2-(4-Methoxyphenyl)-4,5-diphenyl-1-(prop-2-en-1-yl)-1H-imidazole
The asymmetric unit of the title compound, C(25)H(22)N(2)O, contains two independent mol-ecules (A and B), with significantly different conformations. In mol-ecule A, the central imidazole ring makes dihedral angles of 88.26 (10) and 12.74 (11)° with the two phenyl rings, and 22.06 (9)° with the benzene ring. In mol-ecule B, one of the phenyl rings is disordered over two sites, each having an o...
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ژورنال
عنوان ژورنال: International Research Journal of Pharmacy
سال: 2016
ISSN: 2230-8407
DOI: 10.7897/2230-8407.0710116